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Mechanism of insulin resistance in obesity: a role of ATP
《医学前沿(英文)》 2021年 第15卷 第3期 页码 372-382 doi: 10.1007/s11684-021-0862-5
关键词: type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK
PM concentration declining saves health expenditure in China
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1690-4
● Monthly hospitalization expenses are sensitive to increases in PM2.5 exposure.
关键词: Air pollution Health expenditure PM2.5 concentration Economic impact Heterogeneous effect
Mechanisms of insulin resistance in obesity
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 14-24 doi: 10.1007/s11684-013-0262-6
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin resistance. In those hypotheses, inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of attention. Oxidative stress, endoplasmic reticulum (ER) stress, genetic background, aging, fatty liver, hypoxia and lipodystrophy are active subjects in the study of these concepts. However, none of those concepts or views has led to an effective therapy for type 2 diabetes. The reason is that, there has been no consensus for a unifying mechanism of insulin resistance. In this review article, literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance, in which insulin resistance is a result of energy surplus in cells. The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Decreasing ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin resistance. In support, many of existing insulin sensitizing medicines inhibit ATP production in mitochondria. The effective therapies such as weight loss, exercise, and caloric restriction all reduce ATP in insulin sensitive cells. This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity, which may apply to insulin resistance in aging and lipodystrophy.
关键词: type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase (AMPK)
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词: inflammation obesity cytokine energy expenditure insulin resistance
Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 229-234 doi: 10.1007/s11684-010-0028-3
关键词: steroid receptor coactivator-3 white adipose tissue brown adipose tissue obesity adipocytes energy expenditure
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 473-480 doi: 10.1007/s11684-016-0479-
Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.
关键词: maternity insurance scheme financial incentive caesarean delivery medical expenditure China
《能源前沿(英文)》 2022年 第16卷 第6期 页码 931-942 doi: 10.1007/s11708-021-0771-y
关键词: microwave discharge high-energy sites targeted-energy transition morphology design energy efficiency
Analysis of energy saving optimization of campus buildings based on energy simulation
Dingding TONG, Jing ZHAO
《能源前沿(英文)》 2013年 第7卷 第3期 页码 388-398 doi: 10.1007/s11708-013-0273-7
关键词: campus buildings set-point temperature energy simulation energy saving optimization
Modeling China’s energy dilemma: conflicts among energy saving, energy security, and CO 2 mitigation
Feng FU, Zheng LI, Linwei MA,
《能源前沿(英文)》 2010年 第4卷 第3期 页码 295-300 doi: 10.1007/s11708-010-0104-z
关键词: Energy dilemma energy saving energy security CO2 mitigation
Blockchain in energy systems: values, opportunities, and limitations
《能源前沿(英文)》 2022年 第16卷 第1期 页码 9-18 doi: 10.1007/s11708-022-0818-8
关键词: blockchain immutability energy trading energy management data synchronization
Unconventional energy: Seeking the ways to innovate energy science and technology
Jing LIU, Zhixiong GUO
《能源前沿(英文)》 2018年 第12卷 第2期 页码 195-197 doi: 10.1007/s11708-018-0568-9
Impact of household transitions on domestic energy consumption and its applicability to urban energy
Benachir MEDJDOUB, Moulay Larbi CHALAL
《工程管理前沿(英文)》 2017年 第4卷 第2期 页码 171-183 doi: 10.15302/J-FEM-2017029
关键词: urban energy planning household transitions smart cities energy forecasting household projection serious gaming
Dawid P. Hanak, Vasilije Manovic
《化学科学与工程前沿(英文)》 2020年 第14卷 第3期 页码 453-459 doi: 10.1007/s11705-019-1892-2
关键词: carbon capture energy storage renewable energy sources decarbonisation fossil fuels
Levelized costs of the energy chains of new energy vehicles targeted at carbon neutrality in China
《工程管理前沿(英文)》 页码 392-408 doi: 10.1007/s42524-022-0212-6
关键词: energy chain new energy vehicle internal combustion engine vehicle life cycle cost technological learning
《环境科学与工程前沿(英文)》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1549-0
• Framework of indicators was established based on energy efficiency and recovery.
关键词: Wastewater treatment plants Energy neutrality potential Energy efficiency Energy recovery Evaluation framework
标题 作者 时间 类型 操作
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
null
期刊论文
Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expenditure
Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,
期刊论文
Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi, China: a retrospective pre/post-reform case study
null
期刊论文
Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment
期刊论文
Analysis of energy saving optimization of campus buildings based on energy simulation
Dingding TONG, Jing ZHAO
期刊论文
Modeling China’s energy dilemma: conflicts among energy saving, energy security, and CO 2 mitigation
Feng FU, Zheng LI, Linwei MA,
期刊论文
Unconventional energy: Seeking the ways to innovate energy science and technology
Jing LIU, Zhixiong GUO
期刊论文
Impact of household transitions on domestic energy consumption and its applicability to urban energy
Benachir MEDJDOUB, Moulay Larbi CHALAL
期刊论文
Linking renewables and fossil fuels with carbon capture via energy storage for a sustainable energy future
Dawid P. Hanak, Vasilije Manovic
期刊论文
Levelized costs of the energy chains of new energy vehicles targeted at carbon neutrality in China
期刊论文